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Showing 1 to 12 of 53 entries
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Function (Oxford, England)

Stevens BR, Ellory JC, Preston RL.
PMID: 34847569
Function (Oxf). 2021 May 13;2(4):zqab027. doi: 10.1093/function/zqab027. eCollection 2021.

The SARS-CoV-2 receptor, angiotensin-converting enzyme-2 (ACE2), is expressed at levels of greatest magnitude in the small intestine as compared with all other human tissues. Enterocyte ACE2 is coexpressed as the apical membrane trafficking partner obligatory for expression and activity...

Postjunctional M2 Muscarinic Receptors Augment Neurally Mediated Cholinergic Contractions of Murine Airway Smooth Muscle.

Function (Oxford, England)

Ward SM.
PMID: 35028567
Function (Oxf). 2021 Dec 23;3(1):zqab067. doi: 10.1093/function/zqab067. eCollection 2022.

No abstract available.

Heat Treatment Improves Hepatic Mitochondrial Respiratory Efficiency via Mitochondrial Remodeling.

Function (Oxford, England)

Von Schulze AT, Deng F, Fuller KNZ, Franczak E, Miller J, Allen J, McCoin CS, Shankar K, Ding WX, Thyfault JP, Geiger PC.
PMID: 33629069
Function (Oxf). 2021 Jan 22;2(2):zqab001. doi: 10.1093/function/zqab001. eCollection 2021.

Nonacholic fatty liver disease, or hepatic steatosis, is the most common liver disorder affecting the western world and currently has no pharmacologic cure. Thus, many investigations have focused on alternative strategies to treat or prevent hepatic steatosis. Our laboratory...

Ethanol Disrupts Hormone-Induced Calcium Signaling in Liver.

Function (Oxford, England)

Gaspers LD, Thomas AP, Hoek JB, Bartlett PJ.
PMID: 33604575
Function (Oxf). 2021 Jan 08;2(2):zqab002. doi: 10.1093/function/zqab002. eCollection 2021.

Receptor-coupled phospholipase C (PLC) is an important target for the actions of ethanol. In the ex vivo perfused rat liver, concentrations of ethanol >100 mM were required to induce a rise in cytosolic calcium (Ca

Satellite Cell Depletion Disrupts Transcriptional Coordination and Muscle Adaptation to Exercise.

Function (Oxford, England)

Englund DA, Figueiredo VC, Dungan CM, Murach KA, Peck BD, Petrosino JM, Brightwell CR, Dupont AM, Neal AC, Fry CS, Accornero F, McCarthy JJ, Peterson CA.
PMID: 34109314
Function (Oxf). 2020 Nov 23;2(1):zqaa033. doi: 10.1093/function/zqaa033. eCollection 2021.

Satellite cells are required for postnatal development, skeletal muscle regeneration across the lifespan, and skeletal muscle hypertrophy prior to maturity. Our group has aimed to address whether satellite cells are required for hypertrophic growth in mature skeletal muscle. Here,...

Matrix-Bound Growth Factors are Released upon Cartilage Compression by an Aggrecan-Dependent Sodium Flux that is Lost in Osteoarthritis.

Function (Oxford, England)

Keppie SJ, Mansfield JC, Tang X, Philp CJ, Graham HK, Önnerfjord P, Wall A, McLean C, Winlove CP, Sherratt MJ, Pavlovskaya GE, Vincent TL.
PMID: 34423304
Function (Oxf). 2021 Aug 02;2(5):zqab037. doi: 10.1093/function/zqab037. eCollection 2021.

Articular cartilage is a dense extracellular matrix-rich tissue that degrades following chronic mechanical stress, resulting in osteoarthritis (OA). The tissue has low intrinsic repair especially in aged and osteoarthritic joints. Here, we describe three pro-regenerative factors; fibroblast growth factor...

Postjunctional M2 Muscarinic Receptors Augment Neurally Mediated Cholinergic Contractions of Murine Airway Smooth Muscle.

Function (Oxford, England)

Ward SM.
PMID: 35028567
Function (Oxf). 2021 Dec 23;3(1):zqab067. doi: 10.1093/function/zqab067. eCollection 2022.

No abstract available.

A Pathophysiological Model for COVID-19: Critical Importance of Transepithelial Sodium Transport upon Airway Infection.

Function (Oxford, England)

Gentzsch M, Rossier BC.
PMID: 33201937
Function (Oxf). 2020;1(2):zqaa024. doi: 10.1093/function/zqaa024. Epub 2020 Oct 06.

The Coronavirus Disease 2019 (COVID-19) pandemic remains a serious public health problem and will continue to be until effective drugs and/or vaccines are available. The rational development of drugs critically depends on our understanding of disease mechanisms, that is,...

Functions of Presynaptic Voltage-gated Calcium Channels.

Function (Oxford, England)

Dolphin AC.
PMID: 33313507
Function (Oxf). 2021;2(1):zqaa027. doi: 10.1093/function/zqaa027. Epub 2020 Oct 23.

Voltage-gated calcium channels are the principal conduits for depolarization-mediated Ca

Mild Cognitive Impairment and Donepezil Impact Mitochondrial Respiratory Capacity in Skeletal Muscle.

Function (Oxford, England)

Morris JK, McCoin CS, Fuller KN, John CS, Wilkins HM, Green ZD, Wang X, Sharma P, Burns JM, Vidoni ED, Mahnken JD, Shankar K, Swerdlow RH, Thyfault JP.
PMID: 34661111
Function (Oxf). 2021 Sep 02;2(6):zqab045. doi: 10.1093/function/zqab045. eCollection 2021.

Alzheimer's Disease (ad) associates with insulin resistance and low aerobic capacity, suggestive of impaired skeletal muscle mitochondrial function. However, this has not been directly measured in AD. This study (

Sequi Ad Maius Bonum; Targeting Ion Channels in the Lung.

Function (Oxford, England)

Bakowski D, Wood AJ, Parekh AB.
PMID: 34223171
Function (Oxf). 2020 Dec 21;2(1):zqaa045. doi: 10.1093/function/zqaa045. eCollection 2021.

No abstract available.

Capillary Inward-Rectifying K.

Function (Oxford, England)

Jackson WF.
PMID: 34223173
Function (Oxf). 2021 Mar 26;2(3):zqab017. doi: 10.1093/function/zqab017. eCollection 2021.

No abstract available.

Showing 1 to 12 of 53 entries